Wednesday, October 16, 2013

Beat Manifesto: 'Kill Your Darlings,' Figuratively And ...





In Kill Your Darlings, Dane DeHaan (left) plays Lucien Carr, a man whose charm and wit quickly command the attention of the young Allen Ginsberg (Daniel Radcliffe) in their time at Columbia University. John Krokidas' film chronicles the "Libertine Circle" they inhabited — Ginsberg's nickname — and the events that would shatter it.



Clay Enos/Sony Pictures Classics


In Kill Your Darlings, Dane DeHaan (left) plays Lucien Carr, a man whose charm and wit quickly command the attention of the young Allen Ginsberg (Daniel Radcliffe) in their time at Columbia University. John Krokidas' film chronicles the "Libertine Circle" they inhabited — Ginsberg's nickname — and the events that would shatter it.


Clay Enos/Sony Pictures Classics



Kill Your Darlings


  • Director: John Krokidas

  • Genre: Biopic, drama

  • Running Time: 104 minutes

Rated R for sexual content, language, drug use and brief violence.


(Recommended)


With: Daniel Radcliffe, Dane DeHaan, Michael C. Hall



Hollywood's been trying to get a handle on the Beat Poets for years. Allen Ginsberg, William Burroughs and Jack Kerouac led wild — and influential — lives. But films about them, like Naked Lunch and On the Road, have never really clicked with audiences. Kill Your Darlings may fare better, partly because it stars Daniel Radcliffe, and partly because the story centers as much on murder as on poetry.


It's 1943, time for student orientation at Columbia University, and incoming freshman Allen Ginsberg is on a quiet, dignified tour of the campus library when a student with the face of a choirboy leaps on a table with a book.


It's Henry Miller's Tropic of Cancer, and the passage that student reads outrages the librarian enough to get him hauled away by guards, with Ginsberg — as played by Radcliffe with not a hint of Harry Potter about him — grinning broadly.


Truth be told, young Ginsberg is kind of smitten both by the handsome Lucien Carr and by his literary passion. He's soon hanging out with Carr in the dorm, talking poetry and fantasizing about a closer relationship.


Carr (Dane DeHaan), a young man who's anything but a choirboy, and entirely aware of the effect he has on others, soon introduces Ginsberg to a stoned young "Willie" Burroughs (a nice piece of impersonation by actor Ben Foster) and later to Jack Kerouac (Jack Huston). All of them are dreaming of changing the world, but not sure quite how to go about it.





Carr's formidable charisma becomes something of a problem when David (Michael C. Hall), his former lover and professor, won't let go.



Jessica Miglio/Sony Pictures Classics


Carr's formidable charisma becomes something of a problem when David (Michael C. Hall), his former lover and professor, won't let go.


Jessica Miglio/Sony Pictures Classics


They want to supplant Yeats' "Vision" with a "New Vision," but because they're college kids, their literary ambitions often take a back seat to drugs, drinking and pranks, including an elaborately planned but startlingly mild escapade at the Columbia library that gets them in all kinds of trouble.


Bigger trouble, though, is following Carr in the person of an obsessive admirer (Michael C. Hall), a former lover and professor who's long been writing Carr's papers for him — and who has recently been reduced to following him around like a puppy. How Carr deals with that situation gives the story its spine and also a startling climax.


First-time director John Krokidas doesn't make Kill Your Darlings terribly linear. When its heroes go on drug-fueled binges, so does his camera — at one point freezing other patrons at a jazz club in place so the amphetamine-buzzed poets can flit around them. And the director does some flitting of his own, through time with flashbacks, through space with abrupt switches in perspective, and through an eyebrow-notcher of a sequence that conflates three significant penetrations: Burroughs shooting heroin, Ginsberg's first sexual encounter, and the stabbing that will put a period on one fraught situation while creating another one entirely.


In writing circles, the phrase "kill your darlings" usually gets deployed by an editor as advice for a writer who's polished and labored over a favorite sentence so long that all the life has gotten squeezed out of it. "Kill your darling" means get rid of that treasured bit, and find a more natural way to say what you want to say.


The movie Kill Your Darlings is about budding artists who applied that advice to every element of their lives, abolishing rhyme and meter, declaring war on rules, traditions, even people who had the temerity to love them. They flail and they thrash, and Krokidas' film is just like them — as jazz-inflected and freewheeling as the Beat poetry these guys were about to unleash on the world. (Recommended)


Source: http://www.npr.org/2013/10/16/234832821/beat-manifesto-kill-your-darlings-figuratively-and?ft=1&f=1008
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Budget deal thwarts Sarah Palin’s secret plan to impeach Pres. Obama (Americablog)

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Outdoor Technology Privates


We're not going to discuss whether Outdoor Technology has come up with the most unintentionally hilarious name in the history of headphones (the Jays v-Jays still hold that crown). Still, while it's possible the vaguely retro-military style of the Outdoor Technology Privates is the inspiration for the name, it just sounds funny. This pair of $99.95 (direct) Bluetooth headphones provides a significant bass boost without going overboard, and while high end could be a bit more crisp, bass lovers will likely enjoy the sound signature. A detachable cable allows you to listen in wired, non-Bluetooth mode, which is a great extra touch. You are now free to giggle like a child every time I mention the name Privates in this review.



Design
The canvas headband and the square-shaped earcups of the supra-aural (on-ear) Privates evoke something out of Battlefield or Call of Duty. Each pair is available in military green (of course), turquoise, black, or mustard yellow, and is outfitted with black, well-cushioned earpads. The headphones collapse at hinges above the earcups and fold down flat for easy storage, though they do not ship with any sort of carrying pouch.


One great aspect of the Privates' design is the optional audio cable. It's removable and though it has no inline remote control for mobile phones, it allows you to use the headphones as a traditional wired pair when the battery power is low or dead.Outdoor Technology Privates inline


Speaking of pairing, the process is very simple—we had no issues pairing with the iPhone 4S in a matter of seconds. The flashing blue status light that tells you the headphones are paired is quite bright, which is a minor annoyance found on many Bluetooth headphones. In a darker room, it lights things up, and in a brighter room, it still catches the eye.


The capacitive touch surface of the panels on the earcups uses swipes up and down to control volume, and sideways to navigate tracks. The same button you use to pair the headphones controls playback, as well as answering phone calls. The swipes didn't always seem to work, or required repeated swipes to skip a song. Aesthetically speaking, the lack of multiple buttons is nice, but it's not quite as efficient for controlling your music.


The Privates ship with a USB charging cable and the aforementioned 3.5mm, canvas-lined audio cable. Outdoor Technology estimates the battery life to be about 10 hours on a full charge.


Performance
The audio quality of the Privates doesn't change much whether they're connected through Bluetooth mode or the audio cable. On tracks with intense sub-bass content, like the Knife's "Silent Shout," the Privates do not distort and they pump out a powerful bass response. The low-end will appeal to fans of big bass, but things aren't boosted to insane levels.


On Bill Callahan's "Drover," his baritone vocals get a nice richness from the low frequency response, but they could use a bit more treble edge. The drums receive a nice added low frequency presence, but it's not so over-the-top that they compete with the vocals for the spotlight. Things could be crisper overall, but the mix is never muddy.


On Jay-Z and Kanye West's "No Church in the Wild," some added high-mid edge could help the attack of the kick drum loop cut through the mix more. The sub-bass synth hits that punctuate this beat are boosted, but not as intensely as you might hear on other pairs like the Beats by Dr. Dre line-up.


Classical tracks, like John Adams' "The Chairman Dances," sound quite crisp and well-defined through the Privates. Classical tracks tend to retain a decent treble presence to begin with, and typically have less intense bass response that pop mixes, so the bass boosting adds a little richness to the lower register strings and percussion while keeping the spotlight on the higher register strings and the growls of the brass section.


For $100, the Privates are a solid offering, but it's worth perusing the competition, particulalry if you're looking for more presence in the high-mids and highs. If you'd prefer to spend less for sporty design and solid performance, the Outdoor Technology DJ Slims and Editors' Choice Plantronics BackBeat Go 2 both offer a decent Bluetooth experience but not exceptional audio fidelity. If you can spend more on your headphones for audio fidelity, consider the Sennheiser MM 100 or JayBird BlueBuds X


Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/8F2i8-SOXZs/0,2817,2425780,00.asp
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Light triggers death switch in cancer cells

Light triggers death switch in cancer cells


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Public release date: 16-Oct-2013
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Contact: Tomas Llewelyn Barrett
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44-292-087-5596
Cardiff University



Light pulses stimulate designer peptides to initiate a death pathway in cancerous cells



Researchers at Cardiff University have created a peptide (a small piece of protein), linked to a light-responsive dye, capable of switching 'on' death pathways in cancer cells. The peptide remains inactive until exposed to external light pulses which convert it into a cell death signal.


Complex mechanisms in healthy cells normally protect us from developing cancer. However, when the finely balanced networks of interactions between proteins that control such mechanisms are disturbed, uncontrolled cell growth can occur.


The Cardiff team has developed a peptide-switch to alter critical interactions in B-cell lymphoma cancer cells in a 'smart' and controlled way. This new pathway activation technology, called transient photoactivation, may enable scientists to identify cells normally resistant to chemotherapy leading to the development of more effective treatment strategies.


Professor Rudolf Allemann from Cardiff University's School of Chemistry, who led the research, said:


"Whilst killing cancer cells is a goal in itself, this is also proof of a wider principle. Directing therapeutic peptides to the precise location where they are required can be difficult, but activating peptides with light will allow us to precisely define the area where we wish a peptide to act.


"Our research demonstrates that we can control cellular processes with light, which has implications for research in biology and medicine, as our tools can be used to understand the inner workings of cells and to work out how to correct misfiring pathways that lead to disease.


"This work may eventually lead to photo-controlled drugs and tools to probe molecular interactions in intact cells and whole organisms with enormous consequences for biomedical research."


###


This research required the combined expertise of scientists from three Schools at Cardiff (Chemistry, Medicine, and Pharmacy and Pharmaceutical Sciences), who contributed different perspectives and techniques to develop this technology. The findings are published in the journal Molecular Biosystems and can be accessed by clicking here.


The work was funded by an Engineering and Physical Sciences Research Council (EPSRC) grant worth 1.4M.



Useful links:

The School of Chemistry

The School of Medicine

The School of Pharmacy and Pharmaceutical Sciences

For further information or to arrange an interview, please contact:

Tomas Llewelyn Barrett

Public Relations

Cardiff University

Tel: 029 20 875 596

Mobile: 07950792532

E-mail: BarrettTL1@cardiff.ac.uk


Cardiff University

Cardiff University is recognised in independent government assessments as one of Britain's leading teaching and research universities and is a member of the Russell Group of the UK's most research intensive universities. Among its academic staff are two Nobel Laureates, including the winner of the 2007 Nobel Prize for Medicine, University Chancellor Professor Sir Martin Evans. Founded by Royal Charter in 1883, today the University combines impressive modern facilities and a dynamic approach to teaching and research. The University's breadth of expertise encompasses: the College of Humanities and Social Sciences; the College of Biomedical and Life Sciences; and the College of Physical Sciences, along with a longstanding commitment to lifelong learning. Cardiff's three flagship Research Institutes are offering radical new approaches to neurosciences and mental health, cancer stem cells and sustainable places.




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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




Light triggers death switch in cancer cells


[ Back to EurekAlert! ]
Public release date: 16-Oct-2013
[


| E-mail



| Share Share

]

Contact: Tomas Llewelyn Barrett
BarrettTL1@cardiff.ac.uk
44-292-087-5596
Cardiff University



Light pulses stimulate designer peptides to initiate a death pathway in cancerous cells



Researchers at Cardiff University have created a peptide (a small piece of protein), linked to a light-responsive dye, capable of switching 'on' death pathways in cancer cells. The peptide remains inactive until exposed to external light pulses which convert it into a cell death signal.


Complex mechanisms in healthy cells normally protect us from developing cancer. However, when the finely balanced networks of interactions between proteins that control such mechanisms are disturbed, uncontrolled cell growth can occur.


The Cardiff team has developed a peptide-switch to alter critical interactions in B-cell lymphoma cancer cells in a 'smart' and controlled way. This new pathway activation technology, called transient photoactivation, may enable scientists to identify cells normally resistant to chemotherapy leading to the development of more effective treatment strategies.


Professor Rudolf Allemann from Cardiff University's School of Chemistry, who led the research, said:


"Whilst killing cancer cells is a goal in itself, this is also proof of a wider principle. Directing therapeutic peptides to the precise location where they are required can be difficult, but activating peptides with light will allow us to precisely define the area where we wish a peptide to act.


"Our research demonstrates that we can control cellular processes with light, which has implications for research in biology and medicine, as our tools can be used to understand the inner workings of cells and to work out how to correct misfiring pathways that lead to disease.


"This work may eventually lead to photo-controlled drugs and tools to probe molecular interactions in intact cells and whole organisms with enormous consequences for biomedical research."


###


This research required the combined expertise of scientists from three Schools at Cardiff (Chemistry, Medicine, and Pharmacy and Pharmaceutical Sciences), who contributed different perspectives and techniques to develop this technology. The findings are published in the journal Molecular Biosystems and can be accessed by clicking here.


The work was funded by an Engineering and Physical Sciences Research Council (EPSRC) grant worth 1.4M.



Useful links:

The School of Chemistry

The School of Medicine

The School of Pharmacy and Pharmaceutical Sciences

For further information or to arrange an interview, please contact:

Tomas Llewelyn Barrett

Public Relations

Cardiff University

Tel: 029 20 875 596

Mobile: 07950792532

E-mail: BarrettTL1@cardiff.ac.uk


Cardiff University

Cardiff University is recognised in independent government assessments as one of Britain's leading teaching and research universities and is a member of the Russell Group of the UK's most research intensive universities. Among its academic staff are two Nobel Laureates, including the winner of the 2007 Nobel Prize for Medicine, University Chancellor Professor Sir Martin Evans. Founded by Royal Charter in 1883, today the University combines impressive modern facilities and a dynamic approach to teaching and research. The University's breadth of expertise encompasses: the College of Humanities and Social Sciences; the College of Biomedical and Life Sciences; and the College of Physical Sciences, along with a longstanding commitment to lifelong learning. Cardiff's three flagship Research Institutes are offering radical new approaches to neurosciences and mental health, cancer stem cells and sustainable places.




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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




Source: http://www.eurekalert.org/pub_releases/2013-10/cu-ltd101613.php
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How to Get Involved in the Teaching Movement That Could Transform Education








Photo: Peter Yang/WIRED



In the weeks leading up to the publication of our cover story about Sergio Juárez Correa and the students of José Urbina López Primary School, it became clear that WIRED could help. We decided to sponsor the school and Juárez Correa, providing them with supplies and equipment they need, like a projector, printer, and laser pointer.


But there also are powerful ways you can get involved with the burgeoning student-centered style of learning and teaching. Whether you want to bring this approach into an existing school, start a program of your own, donate to a program, or find a teacher who has asked for specific help, we’ve got suggestions. Here are four ways to take action:


1. Last year, the TED prize gave $1 million to Sugata Mitra, one of the movement’s leading thinkers. If you are interested in supporting Mitra and his School in the Cloud project email TEDPrize@TED.com or make contributions payable to:


Sapling Foundation
Care of: TED Prize Team
250 Hudson Street
Suite 1002
NY, NY 10013


2. TED has created a toolkit full of ideas for jumpstarting student-centered learning in your home, local community, or school. It’s called SOLE: How to Bring Self-Organized Learning Environments to Your Community. Download it here and share your story afterward on the SOLE Tumblr.


3. To support or adopt a SOLE classroom (many of which are listed on the SOLE Tumblr) email TEDPrize@TED.com.


4. Support a teacher who has made a specific request for help through DonorsChoose.org, an online charity that connects public school teachers with donors.


Meanwhile, read more about Mitra’s TED Prize at José Urbina López Primary School or watch a preview of the documentary, School in the Cloud, that filmmaker Jerry Rothwell is making about Mitra’s TED prize activities.






Source: http://feeds.wired.com/c/35185/f/661370/s/327d6be8/sc/33/l/0L0Swired0N0Cbusiness0C20A130C10A0Cstudent0Ecentered0Emovement0C/story01.htm
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Putin foe Navalny faces prison if appeal is rejected


By Steve Gutterman


MOSCOW (Reuters) - Convicted at a trial he describes as Vladimir Putin's revenge for his political challenge, Russian opposition leader Alexei Navalny faces five years in prison if his appeal against a theft conviction is rejected on Wednesday.


The court hearing in the remote city of Kirov also poses a conundrum for President Putin.


Jailing Navalny would keep Putin's most prominent critic out of elections for years, curtailing any threat from a young rival with presidential ambitions who scored a strong second-place showing in a Moscow mayoral vote last month.


But it could also revive street protests by Putin's opponents and human rights activists over what they see as a clampdown on dissent since the 61-year-old president started a six-year third term in 2012.


While Putin denies exerting influence over the courts, many Russians suspect that rulings in high-profile cases are dictated by the Kremlin and result from careful political calculation.


"The Kremlin has an unpleasant decision to make," said Dmitry Oreshkin, a political analyst.


A ruling upholding the five-year sentence would be seen by many as evidence that tough tactics will continue despite signals meant to suggest a let-up, such as Putin's promise of a prisoner amnesty later this year.


A blogger against corruption among Russia's elite, Navalny helped lead the biggest protests of Putin's 13-year rule, which were stoked by allegations of fraud in a December 2011 parliamentary election.


The protests have faded, but Navalny has emerged as the main opposition leader, making his trial the most closely watched in Russia since jailed former oil tycoon Mikhail Khodorkovsky's second conviction in 2010.


Accused of stealing timber while working as an adviser to the governor of the Kirov region in 2009, Navalny - who denies wrongdoing - was convicted of large-scale theft in July and sentenced to five years in prison.


FREE FOR NOW


But he was unexpectedly freed from custody the following day to allow him to continue his campaign for Moscow mayor.


Some analysts say the Kremlin was betting he would suffer a humiliating defeat, but he won 27 percent and nearly forced the incumbent, Putin ally Sergei Sobyanin, into a runoff.


"It's difficult for the Russian authorities to jail Navalny, because he has won legitimacy in the form of support from 600,000 people who voted for him," said Liliya Shevtsova, a senior associate at the Carnegie Moscow Center thinktank.


Because Navalny's popularity is limited in Russia's far-flung regions and Putin faces no imminent threat to his rule, Shevtsova said that for the Kremlin it would make little sense to "turn Navalny into a Russian Mandela".


While many analysts expect Navalny's conviction will stand, some predict his sentence might be reduced or suspended, keeping him out of prison but also out of elections.


Some cautioned, however, that his chances of staying out of jail should not be overestimated.


"Putin's power structure instinctively follows the standards of the Stalin or Brezhnev era, when inconvenient and critical people were isolated," Oreshkin said. "The temptation to do that with Navalny will be great."


Navalny, who used a smartphone to send tweets during his trial, kept up his anti-corruption campaign on the eve of the hearing with a blog post about an enormous apartment allegedly owned by the wife of an ice hockey star turned lawmaker.


He maintained a wry air on Twitter, writing: "I'm really tired of going to Kirov and it's cold there :("


In response to an invitation to a performance at a Kirov theatre on Wednesday evening, he tweeted: "I'll be there of course".


(Additional reporting by Maria Tsvetkova; Editing by Robin Pomeroy and Ralph Boulton)



Source: http://news.yahoo.com/putin-foe-navalny-faces-prison-appeal-rejected-205205022.html
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Tuesday, October 15, 2013